This may be counter intuitive but I find that a lot of times in smaller niches you are better off with fewer ads. For example, if you have a skyscaper ad running in a low visibility sidebar location appearing higher in the source code than 2 other ads your ePC (earnings per click) will probably be very low. The reason for this is you might have $1-2 ads in your sidebar not getting clicks while your content ads are only pulling $.20 per click. I find that running 2-3 ad units with 1 text ad each seems to be a good strategy for maximizing ePC and eCPM in a lot of cases.